Wegener's granulomatosis: A model of auto-antibodies in mucosal autoimmunity
نویسندگان
چکیده
منابع مشابه
ENT manifestations of Wegeners granulomatosis.
Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...
متن کاملThe Role of Anca and Anti-gbm Antibodies in Pulmonary- Renal Syndrom Due to Wegeners Granulomatosis
Pulmonary-renal syndrome (PRS) is defined as a diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. We present a retrospective study of 22 consecutive patients with Wegeners granulomatosis (WG). Logistic regression analysis and a Wilcoxon test were included in the statistics. Survival time death risk were assessed using the Kaplan-Meier estimator and the Cox proportional haz...
متن کاملNeutrophil chemotaxis in Wegeners granulomatosis and idiopathic pulmonary fibrosis
Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegeners granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...
متن کاملAnticytoplasmic antibodies in Wegener's granulomatosis.
Wegener 's granulomatos is , a d isease of unknown et io logy, is character ized by a granulomatous vascul i t is of the upper and lower r e s p i r a t o r y t r a c t s . Va r y i n g d e g r e e s o f s y s t e m i c v a s c u l i t i s o f s m a l l arter ies and veins may also be seen <1>. Renal disease in the form of f o c a l o r d i f f u s e n e c r o t i z i n g g l o m e r u l i t i ...
متن کاملWegener's granulomatosis--autoimmunity to neutrophil proteinase 3.
Wegener's granulomatosis (WG) is a small-vessel vasculitis associated with various clinical manifestations, among which the most common are respiratory tract disease and glomerulonephritis leading to renal failure. The pathogenesis of vascular injury in WG is ascribed to antineutrophil cytoplasmic antibodies (ANCA) directed mainly against proteinase 3 (PR3), an enzyme from neutrophil granules. ...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2010
ISSN: 1521-6616
DOI: 10.1016/j.clim.2009.04.014